If the American League walks away with a win at Tuesday night's MLB All-Star Game at Marlins Park, they would even the overall All-Star series record at 43-43(-2).
For this year's match up, Chicago Cubs manager Joe Maddon has tabbed the Washington Nationals' Max Scherzer (10-5, 2.10 ERA) as the National Leagues's starting pitcher. Clayton Kershaw, of the Los Angeles Dodgers, started on Sunday and will be skipping the All-Star Game.
The American League will see Boston Red Sox ace Chris Sale (11-4, 2.75) first on the mound, as he has gotten off to another strong start in his first year with the team. The six-time All-Star has the most strikeouts in baseball with 178, which is five more than NL leader Scherzer.
While the All-Star Game has historically been evenly matched, the last few decades have been tilted heavily in the American League's favor.
The AL has gone 22-6-1 in its last 29 games against the NL, shaking off a three-game winning streak by the NL from 2010 to 2012 with four straight wins.
The AL-leading Houston Astros will be represent three of the top five bats in the starting lineup with Jose Altuve, George Springer, and Carlos Correa. Monday night's Home Run Derby winner Aaron Judge will bat third.
Home-field advantage may not help the National League as the American League is 7-1 in its last eight games played in NL parks. But then again, the odds are only odds, and tonight's face off will ultimately have to speak for itself.
Here's everything else you need to know:
When is the 2017 MLB All-Star Game?
Tuesday, July 11, at 8 p.m. ET on FOX.
Starting Lineups
American League
1. Jose Altuve, Houston Astros
2. Jose Ramirez, Cleveland Indians
3. Aaron Judge, New York Yankees
4. George Springer, Houston Astros
5. Carlos Correa, Houston Astros
6. Justin Smoak, Toronto Blue Jays
7. Corey Dickerson, Tampa Bay Rays
8. Salvador Perez, Kansas City Royals
9. Mookie Betts, Boston Red Sox
Starting Pitcher: Chris Sale, Chicago White Sox
National League
1. Charlie Blackmon, CF, Colorado Rockies
2. Giancarlo Stanton, DH, Miami Marlins
3. Bryce Harper, RF, Washington Nationals
4. Buster Posey, C, San Francisco Giants
5. Daniel Murphy, 2B, Washington Nationals
6. Nolan Arenado, 3B, Colorado Rockies
7. Ryan Zimmerman, 1B, Washington Nationals
8. Marcell Ozuna, LF, Miami Marlins
9. Zack Cozart, SS, Cincinnati Reds
Starting Pitcher: Max Scherzer, Washington Nationals
American League Complete Roster
CATCHERS: Salvador Perez (Royals), Gary Sanchez (Yankees)
INFIELDERS: Justin Smoak (Blue Jays); Jose Altuve (Astros); Carlos Correa (Astros); Jose Ramirez (Indians); Jonathan Schoop (Orioles); Francisco Lindor (Indians); Miguel Sano (Twins); Yonder Alonso (Athletics); Starlin Castro (Yankees)
OUTFIELDERS: Aaron Judge (Yankees); Mike Trout (Angels); George Springer (Astros); Mookie Betts (Red Sox); Michael Brantley (Indians); Avisail Garcia (White Sox)
DESIGNATED HITTERS: Corey Dickerson (Rays); Nelson Cruz (Mariners)
PITCHERS: Chris Sale (Red Sox); Ervin Santana (Twins); Jason Vargas (Royals); Corey Kluber (Indians); Andrew Miller (Indians); Craig Kimbrel (Red Sox); Dallas Keuchel (Astros); Luis Severino (Yankees); Yu Darvish (Rangers); Michael Fulmer (Tigers); Lance McCullers Jr. (Astros); Dellin Betances (Yankees)
MANAGER: Terry Francona (Indians)
National League Complete Roster
CATCHERS: Buster Posey (Giants); Yadier Molina (Cardinals)
INFIELDERS: Ryan Zimmerman (Nationals); Daniel Murphy (Nationals); Zack Cozart (Reds); Nolan Arenado (Rockies); Corey Seager (Dodgers); Jake Lamb (Diamondbacks); Cody Bellinger (Dodgers); Paul Goldschmidt (Diamondbacks); Joey Votto (Reds); DJ LeMahieu (Rockies); Josh Harrison (Pirates)
OUTFIELDERS: Marcell Ozuna (Marlins); Charlie Blackmon (Rockies); Bryce Harper (Nationals); Michael Conforto (Mets); Giancarlo Stanton (Marlins); Ender Inciarte (Braves)
PITCHERS: Clayton Kershaw (Dodgers); Max Scherzer (Nationals); Carlos Martinez (Cardinals); Robbie Ray (Diamondbacks); Greg Holland (Rockies); Kenley Jansen (Dodgers); Zack Greinke (Diamondbacks); Stephen Strasburg (Nationals); Wade Davis (Cubs); Brad Hand (Padres); Corey Knebel (Brewers); Pat Neshek (Phillies)
MANAGER: Joe Maddon (Cubs)